Mourinho-coached United is set to play the last match of this season's EPL campaign at home with Crystal Palace on Sunday.
United will finish sixth regardless of the outcome of their match with Palace, who are also safe from relegation with three teams already down, and because of its insignificance Mourinho is disappointed English football authorities have not intervened.
Ajax manager Peter Bosz has warned Jose Mourinho not to use fatigue as an excuse if Manchester United fall short against his team in the Europa League.
"I hope Big Sam shows he is a good friend and he asks Wilfried Zaha to go slow and leaves Chrsitian Benteke at home and they go soft on us", Mourinho said.
It will not just be kids playing against Palace as Mourinho confirmed Paul Pogba will start after missing the past two matches following the death of his father.
English Premier League footballclub Manchester United raised its full-year revenue and profit forecast for 2016-2017 as it prepares for the Europa League final next week. I feel no pressure, just the pressure that everyone dreams of in these moments.
Puel said: "This team has great players and a strong squad".
James Rodriguez, Antoine Griezmann and Romelu Lukaku are rumoured to be transfer targets of the Red Devils but according to reports in England all of them could snub a move to the Old Trafford in case the Red Devils don't play in Champions League next season.
I was really tempted to pick a draw here, given how meaningless this match is for both sides, but with United playing so many kids, my gut feeling is that a couple of them will treat this match like a trophy tilt and rise up to the occasion.
Mourinho will essentially treat this like a friendly, as he'll play what could be as many as nine U23s in this one.
Mourinho added: "I cannot go to Man City or Arsenal and put out five kids at the same time altogether".
"I always disagree with it, I don't think a team should play in two European competitions in the same season".
'These are examples of trying not to accumulate when people have to play because we do not have other players and I cannot put four or five kids all together in the fire.