However, two Romanian players made it to the second round of the tournament.
The Romanian has been suffering from the injury since late previous year, undergoing non-invasive treatment, while taking anti-inflammatory medication over the last couple of days, though she hasn't seen a doctor yet to determine if surgery is needed.
Williams has not won a grand slam since 2008 and has also never tasted Australian Open glory, with her closest effort coming in 2003, where she lost in the final.
Rogers' game is very powerful as she feels very comfortable playing on the offense, and that would help in the match as she should be able to overpower Halep when it concerns the attack.
The five-time finalist started on Rod Laver Arena on Monday, taking the first step in his bid for a first Australian Open title. "When I lost the second set, and I had match point, I was thinking about my match a year ago in the first round - first rounds are always tough".
"The biggest thing I took away from that was just that I can compete with the top players in the world and I'm good enough", the 24-year-old said.
"It's hard to play with the pain, and the knees are risky, so I have to take care". There has been a lot of positive feedback, which has been nice.
Playing the first match of the tournament on centre court, Rogers held serve first up when Halep sent a backhand wide as both players adjusted to the conditions.
Rogers was supreme in the tight moments, saving the only break point she faced and also winning 66 per cent of her second serve points, along with the 26 winners that she clubbed.
The usually tenacious Halep was clearly struggling and she called for the trainer at the changeover.
She will meet the victor of Australian Ash Barty and German Annika Beck in the second round.
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